"'One Tree Hill' will always be very, very special to me. It was my first television show. And my first gig in the business. It was surreal. I booked the role when I was 13. I had just started high school, and literally, I think, a week into high school, I found out I got the role. It was unimaginable! I learned so much from that show."
Chow was born to a Chinese father and a mother of English and Cherokee descent. She was born in Columbia, South Carolina; she speaks very little Mandarin. She has two younger siblings: a brother who is two years younger and a sister who is eight years younger. She attended Hammond School for high school, located in Columbia, SC. Kelsey Chow's main residence is in Los Angeles, California, but she currently lives in New York City where she attends Columbia University.
After gaining experience in community theatre, Chow got her first television role in 2005 where she played the recurring role of Gigi Silveri on One Tree Hill at the age of 13 appearing on the show until 2009. In 2008, she guest starred on The Suite Life of Zack & Cody. She also co-starred in the Disney Channel original film, Den Brother. From 2010 to 2013, Chow co-starred as Mikayla on Disney XD original series, Pair of Kings. In 2012, Chow had a small part in The Amazing Spider-Man, and was later cast in the feature film Run. In 2014, she was cast in the Fox drama Hieroglyph. However, the series was cancelled before it premiered. In early 2015, she guest starred in The Goldbergs in the second season along with David Schwimmer. She later co-starred in the music video for Hayley Kiyoko's song "Girls Like Girls". Kelsey appeared in the recurring role of Tracy Stewart on season 5, part 1 of Teen Wolf, which premiered on June 29, 2015.